참고문헌

검증에 사용한 동료심사 논문·리뷰 10편입니다. 근거의 강도는 연구 유형 순으로 정렬했습니다(사람 임상 → 동물 → 세포 → 리뷰). 확인된 식별자(DOI/PMID/PMC)만 표기했으며, 확인되지 않은 값은 임의로 채우지 않았습니다.

Human RCT · 2편

Human RCTNutrients · 2023

Benefits of Wasabi Supplements with 6-MSITC on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial

Nouchi R, Kawata NYS, Saito T, Nouchi H, Kawashima R

72 healthy adults aged 60+ took 0.8 mg/day 6-MSITC or placebo for 12 weeks. The 6-MSITC group showed significant improvement in working and episodic memory versus placebo; no significant change in other cognitive domains. First human RCT evidence for the brain-health claim — but small and single-study.

PMID: 37960261 PMC: PMC10648564

Human RCTJapanese Pharmacology & Therapeutics · 2019

The Effects of Wasabi Root-derived 6-(methylsulfinyl)hexyl Isothiocyanate on Neurocognitive Functions in Cognitively Intact Middle-aged and Older Adults — A Randomized, Double-blind, Placebo-controlled Trial

Okunishi K, et al.

Earlier randomized, double-blind, placebo-controlled trial of wasabi-derived 6-MSITC on neurocognitive function in cognitively intact middle-aged and older adults. Adds a second human data point for the cognition claim.

Human trial · 1편

Human trialFunctional Foods in Health and Disease · 2023

Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers

Kawakami S, et al.

Human volunteer study reporting that oral 6-MSITC is safe and improves self-reported fatigue and sleep. Adds human safety data relevant to the general wellness positioning.

PMC: PMC10463496

Animal · 1편

AnimalFoods · 2022

Wasabi (Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats

du Preez R, Wanyonyi S, Mouatt P, Panchal SK, Brown L

In a rat model of diet-induced metabolic syndrome, wasabi reduced body-fat measures and blood pressure. Animal evidence for the fat-reduction claim — not yet demonstrated in humans.

DOI: 10.3390/foods11213435 PMC: PMC9654917

In vitro · 3편

In vitroFrontiers in Microbiology · 2016

Antibacterial Activities of Wasabi against Escherichia coli O157:H7 and Staphylococcus aureus

Lu Z, Dockery CR, Crosby M, Chavarria K, Patterson B, Giedd M

Wasabi showed strong antibacterial activity against E. coli O157:H7 and S. aureus (MIC ≈ 1% / 10 mg/mL), with allyl isothiocyanate (AITC) as the major active compound. Laboratory evidence for the antimicrobial / food-preservation claim.

PMC: PMC5030237

In vitroGene Regulation and Systems Biology · 2016

DNA Microarray Highlights Nrf2-Mediated Neuron Protection Targeted by Wasabi-Derived Isothiocyanates in IMR-32 Cells

Trio PZ, Fujisaki S, Tanigawa S, Hisanaga A, Sakao K, Hou DX

In human neuroblastoma (IMR-32) cells, wasabi isothiocyanates activated the Nrf2–antioxidant response element pathway, upregulating phase II antioxidant/detox enzymes. Cell-culture evidence for the antioxidant and 'detox' mechanisms.

DOI: 10.4137/GRSB.S39440

In vitroPLOS ONE / Gene Regulation and Systems Biology · 2016

DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells

Trio PZ, You S, He X, He J, Sakao K, Hou DX

In liver (HepG2) cells, wasabi-derived isothiocyanates drove Nrf2-mediated induction of detoxifying/phase-II enzymes. Supports the biochemical basis of the antioxidant + detoxification claims, at the cellular level only.

PMID: 27911093

Review · 2편

ReviewNutrients · 2024

Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity

Bartkowiak-Wieczorek J, Malesza M, Malesza I, Hadada T, Winkler-Galicki J, Grzelak T, Mądry E

Comprehensive review of 6-MSITC mechanisms (Nrf2/Keap1-ARE, NF-κB, PPAR, AMPK, PI3K/AKT/mTOR). Notes anti-oxidant, anti-inflammatory, neuroprotective and anti-obesity effects — but explicitly states the molecule 'has not yet been thoroughly tested in the human population.' Documents human doses of 0.8–16 mg/day 6-MSITC.

DOI: 10.3390/nu16152509 PMID: 39125389 PMC: PMC11313713

ReviewBiomedicines · 2024

Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane

Mangla B, et al.

Review of how isothiocyanates suppress inflammation via NF-κB/AP-1 inhibition and reduced iNOS, COX-2 and IL-6. Mechanistic support for the anti-inflammatory claim across the isothiocyanate class (sulforaphane, of which 6-MSITC is an analog).

DOI: 10.3390/biomedicines12061169 PMID: 38927376

Narrative review · 1편

Narrative reviewJournal of Functional Foods (Elsevier) · 2025

The multifaceted benefits of wasabi herbal supplements: Enhancing immune function, cognitive performance, and physical endurance (narrative review)

et al.

Narrative review aggregating claims around wasabi supplements for immunity, cognition and endurance. Useful overview, but a narrative (non-systematic) review — lowest weight of evidence and should not be read as proof.